Effect of some bisbenzylisoquinoline alkaloids on American Leishmania sp. in BALB/c mice

Alain Fournet, Alcira Angelo Barrios, Victoria Muñoz Ortiz, Reynald Hocquemiller, André Cavé

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Four bisbenzylisoquinoline alkaloids, antioquine, berbamine, gyrocarpine and isotetrandrine were tested in BALB/c mice infected with Leishmania amazonensis (IFLA/BR/67/PH8 or MHOM/GF/84/CAY‐H‐142) or L. venezuelensis (VE/74/PM‐H3). The treatments were initiated 1 day after the parasitic infection, with alkaloid at 100 mg/kg/day for 14 days and the reference compound, meglumine antimonate (GlucantimeR) at 200 mg/kg/day. Antioquine, berbamine and gyrocarpine were less potent than Glucantime against L. amazonensis (PH8). Only isotetrandrine exhibited activity approximately equal to or greater than Glucantime in BALB/c mice infected with L. amazonensis (PH8 or H‐142) and showed significant activity against L. venezuelensis. Experiments with a single local treatment on the footpad, 2 weeks after parasitic infection with L. amazonensis (PH8), showed that isotetrandrine at 200 mg/kg was less active than Glucantime at 400 mg/kg.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalPhytotherapy Research
Volume7
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • antioquine
  • BALB/c mice
  • berbamine
  • bisbenzylisoquinoline alkaloids
  • gyrocarpine
  • isotetrandrine
  • L. venezuelensis
  • Leishmania amazonensis

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