Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity

Vanessa Duarte Claudino, Kesia Caroline da Silva, Valdir Cechinel Filho, Rosendo Augusto Yunes, Franco Delle Monache, Alberto Giménez, Efrain Salamanca, David Gutierrez-Yapu, Angela Malheiros

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25 Scopus citations


This paper evaluates CHCl3 and CH3OH extracts of the stem bark, branches and leaves of Drimys brasiliensis and drimane sesquiterpenes isolated from the stem bark against strains of Leishmania amazonensis and Leishmania braziliensis promastigotes and Plasmodium falciparum trophozoites. All of the extracts and compounds were tested in cell lines in comparison with reference standards and cell viability was determined by the XTT method. The CHCl3 and CH3OH extracts from the stem bark and branches yielded promising results against two strains of Leishmania, with 50% inhibitory concentrations (IC50) values ranging from 39-100 μg/mL. The CHCl3 extract of the stem bark returned IC50 values of 39 and 40.6 μg/mL for L. amazonensis and L. braziliensis, respectively. The drimanes were relatively effective: 1-β-(p-coumaroyloxy)-polygodial produced IC50 values of 5.55 and 2.52 μM for L. amazonensis and L. braziliensis, respectively, compared with 1-β-(p-methoxycinnamoyl)-polygodial, which produced respective IC50 values of 15.85 and 17.80 μM. The CHCl3 extract demonstrated activity (IC50 of 3.0 μg/mL) against P. falciparum. The IC50 values of 1-β-(p-cumaroyloxyl)-polygodial and 1-β-(p-methoxycinnamoyl)-polygodial were 1.01 and 4.87 μM, respectively, for the trophozoite strain. Therefore, the results suggest that D. brasiliensis is a promising plant from which to obtain new and effective antiparasitic agents.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalMemorias do Instituto Oswaldo Cruz
Issue number2
StatePublished - Apr 2013


  • Drimane sesquiterpenes
  • Drimys
  • Leishmaniasis
  • Malaria


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