Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 μg/mL and 7.5 μg/mL, respectively).
Bibliographical noteFunding Information:
The authors wish to thank Paulino Simá-Polanco and Lourdes Morales-Dzul for collecting, identifying and preparing the plant material, as well as Fabiola Escalante-Erosa and Karlina García-Sosa, for technical assistance. G.E.-R. wishes to thank the European Commission for financial support via the EULADIV Alfa Project. The authors also gratefully acknowledge financial support from the Swedish Natural Science Research Council, the KAW foundation, the Swedish Foundation for International Cooperation in Research and Higher Education, and FOMIX-Yucatán Project No. 66262.
- Bourreria pulchra
- Leishmania mexicana
- Trypanosoma cruzi