Arsenic exposure and metabolism among women in Bolivia

J. Gardon, N. Tirado, K. Broberg, M. Vahter

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Inorganic arsenic (iAs) in drinking water is found in south regions of Bolivia, but human exposure and metabolism efficiency remain unknown. Inefficient methylation of arsenic with a low fraction of DMA in urine is a susceptibility factor for toxic effects. To elucidate arsenic exposure and metabolism in different Bolivian population groups, 74 women from communities (Llapallapani, Pampa-Aullagas, Quillacas) around Lake Poopó were recruited. Arsenic exposure was assessed by the sum of arsenic metabolites (iAs, MMA, DMA) in urine (U-As) using HPLC-HG-ICPMS. The efficiency of arsenic metabolism was expressed as the percentages of the metabolites. The median U-As was 62.2, 62.3 and 83.9 μg/L and the median%DMA was 83.0, 81.3 and 79.1% in Llapallapani, Pampa Aullagas and Quillacas, respectively. Women in Llapallapani had a significantly higher fraction of DMA. The women showed elevated arsenic exposure and an efficient arsenic metabolism, which might influence their risk for arsenic-related disease.

Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
EditorsProsun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
PublisherCRC Press/Balkema
Pages392-393
Number of pages2
ISBN (Print)9781138029415
DOIs
StatePublished - 2016
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: 19 Jun 201623 Jun 2016

Publication series

NameArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
Country/TerritorySweden
CityStockholm
Period19/06/1623/06/16

Bibliographical note

Publisher Copyright:
© 2016 Taylor & Francis Group, London.

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