Antiprotozoal activity of ethanol extracts of some Bomarea species

Fernando Alzate; Nora Jimenez; Bernard Weniger; Jaume Bastida; Alberto José Gimenez Turba; Grace Ruiz

doi:10.1080/13880200801968904

Antiprotozoal activity of ethanol extracts of some Bomarea species

Fernando Alzate, Nora Jimenez, Bernard Weniger, Jaume Bastida, Alberto José Gimenez Turba, Grace Ruiz

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The antiprotozoal activity of 26 ethanol extracts derived from 13 species of the genus Bomarea (Alstroemeriaceae) were evaluated against the promastigote forms of three Leishmania species (L. amazonensis L., L. braziliensis Vianna, and L. donovani Laveran & Mesnil) and the epimastigote form of Trypanosoma cruzi Chagas. IC50 values for leishmanicidal activities were between 4.9 and 98.6 μg/mL, B. setacea extracts being the most active against the three species of Leishmania. Amphotericin B (IC50 = 0.2 μg/mL) and pentamidine (IC50 = 10 μg/mL) were used as control in this assay. IC50 values for antitrypanosomal activities were between 65.2 and 92.7 μg/mL, whereas the control benznidazole had an IC50 value of 2 μg/mL.

Original language	English
Pages (from-to)	575-578
Number of pages	4
Journal	Pharmaceutical Biology
Volume	46
Issue number	9
DOIs	https://doi.org/10.1080/13880200801968904
State	Published - Sep 2008

Bibliographical note

Funding Information:
The authors thank Edison Osorio, Guillermo Montoya and Katalina Muños for technical support and useful comments on the manuscript. This work was partially supported by the Colombian Institute for Science Development (Colcien-cias).

Keywords

Alstroemeriaceae
Antitrypanosomal activity
Biodiversity
Bomarea
Leishmanicidal activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13880200801968904

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title = "Antiprotozoal activity of ethanol extracts of some Bomarea species",

abstract = "The antiprotozoal activity of 26 ethanol extracts derived from 13 species of the genus Bomarea (Alstroemeriaceae) were evaluated against the promastigote forms of three Leishmania species (L. amazonensis L., L. braziliensis Vianna, and L. donovani Laveran & Mesnil) and the epimastigote form of Trypanosoma cruzi Chagas. IC50 values for leishmanicidal activities were between 4.9 and 98.6 μg/mL, B. setacea extracts being the most active against the three species of Leishmania. Amphotericin B (IC50 = 0.2 μg/mL) and pentamidine (IC50 = 10 μg/mL) were used as control in this assay. IC50 values for antitrypanosomal activities were between 65.2 and 92.7 μg/mL, whereas the control benznidazole had an IC50 value of 2 μg/mL.",

keywords = "Alstroemeriaceae, Antitrypanosomal activity, Biodiversity, Bomarea, Leishmanicidal activity",

author = "Fernando Alzate and Nora Jimenez and Bernard Weniger and Jaume Bastida and {Gimenez Turba}, {Alberto Jos{\'e}} and Grace Ruiz",

note = "Funding Information: The authors thank Edison Osorio, Guillermo Montoya and Katalina Mu{\~n}os for technical support and useful comments on the manuscript. This work was partially supported by the Colombian Institute for Science Development (Colcien-cias).",

year = "2008",

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doi = "10.1080/13880200801968904",

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volume = "46",

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AU - Alzate, Fernando

AU - Jimenez, Nora

AU - Weniger, Bernard

AU - Bastida, Jaume

AU - Gimenez Turba, Alberto José

AU - Ruiz, Grace

N1 - Funding Information: The authors thank Edison Osorio, Guillermo Montoya and Katalina Muños for technical support and useful comments on the manuscript. This work was partially supported by the Colombian Institute for Science Development (Colcien-cias).

PY - 2008/9

Y1 - 2008/9

N2 - The antiprotozoal activity of 26 ethanol extracts derived from 13 species of the genus Bomarea (Alstroemeriaceae) were evaluated against the promastigote forms of three Leishmania species (L. amazonensis L., L. braziliensis Vianna, and L. donovani Laveran & Mesnil) and the epimastigote form of Trypanosoma cruzi Chagas. IC50 values for leishmanicidal activities were between 4.9 and 98.6 μg/mL, B. setacea extracts being the most active against the three species of Leishmania. Amphotericin B (IC50 = 0.2 μg/mL) and pentamidine (IC50 = 10 μg/mL) were used as control in this assay. IC50 values for antitrypanosomal activities were between 65.2 and 92.7 μg/mL, whereas the control benznidazole had an IC50 value of 2 μg/mL.

AB - The antiprotozoal activity of 26 ethanol extracts derived from 13 species of the genus Bomarea (Alstroemeriaceae) were evaluated against the promastigote forms of three Leishmania species (L. amazonensis L., L. braziliensis Vianna, and L. donovani Laveran & Mesnil) and the epimastigote form of Trypanosoma cruzi Chagas. IC50 values for leishmanicidal activities were between 4.9 and 98.6 μg/mL, B. setacea extracts being the most active against the three species of Leishmania. Amphotericin B (IC50 = 0.2 μg/mL) and pentamidine (IC50 = 10 μg/mL) were used as control in this assay. IC50 values for antitrypanosomal activities were between 65.2 and 92.7 μg/mL, whereas the control benznidazole had an IC50 value of 2 μg/mL.

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KW - Biodiversity

KW - Bomarea

KW - Leishmanicidal activity

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JF - Pharmaceutical Biology

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ER -

Antiprotozoal activity of ethanol extracts of some Bomarea species

Abstract

Bibliographical note

Keywords

UN SDGs

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