Antiprotozoal activity of ethanol extracts of some Bomarea species

Fernando Alzate, Nora Jimenez, Bernard Weniger, Jaume Bastida, Alberto José Gimenez Turba, Grace Ruiz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The antiprotozoal activity of 26 ethanol extracts derived from 13 species of the genus Bomarea (Alstroemeriaceae) were evaluated against the promastigote forms of three Leishmania species (L. amazonensis L., L. braziliensis Vianna, and L. donovani Laveran & Mesnil) and the epimastigote form of Trypanosoma cruzi Chagas. IC50 values for leishmanicidal activities were between 4.9 and 98.6 μg/mL, B. setacea extracts being the most active against the three species of Leishmania. Amphotericin B (IC50 = 0.2 μg/mL) and pentamidine (IC50 = 10 μg/mL) were used as control in this assay. IC50 values for antitrypanosomal activities were between 65.2 and 92.7 μg/mL, whereas the control benznidazole had an IC50 value of 2 μg/mL.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalPharmaceutical Biology
Volume46
Issue number9
DOIs
StatePublished - Sep 2008

Bibliographical note

Funding Information:
The authors thank Edison Osorio, Guillermo Montoya and Katalina Muños for technical support and useful comments on the manuscript. This work was partially supported by the Colombian Institute for Science Development (Colcien-cias).

Keywords

  • Alstroemeriaceae
  • Antitrypanosomal activity
  • Biodiversity
  • Bomarea
  • Leishmanicidal activity

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