Antiprotozoal activity of Betulinic acid derivatives

D. B. Domínguez-Carmona; F. Escalante-Erosa; K. García-Sosa; G. Ruiz-Pinell; D. Gutierrez-Yapu; M. J. Chan-Bacab; A. Giménez-Turba; L. M. Peña-Rodríguez

doi:10.1016/j.phymed.2009.08.002

Antiprotozoal activity of Betulinic acid derivatives

D. B. Domínguez-Carmona, F. Escalante-Erosa, K. García-Sosa, G. Ruiz-Pinell, D. Gutierrez-Yapu, M. J. Chan-Bacab, A. Giménez-Turba, L. M. Peña-Rodríguez

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

Original language	English
Pages (from-to)	379-382
Number of pages	4
Journal	Phytomedicine
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.phymed.2009.08.002
State	Published - Apr 2010

Keywords

Antiplasmodial
Betulinic acid
Leishmanicidal
Pentalinon andriexii
Trypanocidal

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10.1016/j.phymed.2009.08.002

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title = "Antiprotozoal activity of Betulinic acid derivatives",

abstract = "Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.",

keywords = "Antiplasmodial, Betulinic acid, Leishmanicidal, Pentalinon andriexii, Trypanocidal",

author = "Dom{\'i}nguez-Carmona, {D. B.} and F. Escalante-Erosa and K. Garc{\'i}a-Sosa and G. Ruiz-Pinell and D. Gutierrez-Yapu and Chan-Bacab, {M. J.} and A. Gim{\'e}nez-Turba and Pe{\~n}a-Rodr{\'i}guez, {L. M.}",

year = "2010",

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doi = "10.1016/j.phymed.2009.08.002",

language = "Ingl{\'e}s",

volume = "17",

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journal = "Phytomedicine",

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publisher = "Urban und Fischer Verlag Jena",

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TY - JOUR

T1 - Antiprotozoal activity of Betulinic acid derivatives

AU - Domínguez-Carmona, D. B.

AU - Escalante-Erosa, F.

AU - García-Sosa, K.

AU - Ruiz-Pinell, G.

AU - Gutierrez-Yapu, D.

AU - Chan-Bacab, M. J.

AU - Giménez-Turba, A.

AU - Peña-Rodríguez, L. M.

PY - 2010/4

Y1 - 2010/4

N2 - Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

AB - Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

KW - Antiplasmodial

KW - Betulinic acid

KW - Leishmanicidal

KW - Pentalinon andriexii

KW - Trypanocidal

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U2 - 10.1016/j.phymed.2009.08.002

DO - 10.1016/j.phymed.2009.08.002

M3 - Artículo

C2 - 19748254

AN - SCOPUS:77049100021

SN - 0944-7113

VL - 17

SP - 379

EP - 382

JO - Phytomedicine

JF - Phytomedicine

IS - 5

ER -

Antiprotozoal activity of Betulinic acid derivatives

Abstract

Keywords

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