Antiprotozoal activity of Betulinic acid derivatives

D. B. Domínguez-Carmona, F. Escalante-Erosa, K. García-Sosa, G. Ruiz-Pinell, D. Gutierrez-Yapu, M. J. Chan-Bacab, A. Giménez-Turba, L. M. Peña-Rodríguez

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
Issue number5
StatePublished - Apr 2010


  • Antiplasmodial
  • Betulinic acid
  • Leishmanicidal
  • Pentalinon andriexii
  • Trypanocidal


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