Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 μg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Bibliographical noteFunding Information:
This research was supported by the Swedish International Development Agency (Sida) for a project on Plant biodiversity as a collaboration between University Major of San Andres, La Paz, Bolivia and Lund University, Sweden . Lund University is a member of the EU NoE ECNIS, which partly supported the study. This work was also supported by NIH ( 1R01A136596 ) and CDC ( U01/CI00211-02 ). The Natural Resource Conservation Authority, Jamaica and Discovery Bay Marine Laboratory are gratefully acknowledged for assistance with sample collections.
- Cell proliferation