Antiproliferative activity of extracts of some Bolivian medicinal plants

Gloria C. Rodrigo, Giovanna Rocio Almanza Vega Almanza Vega, Bjorn Akesson, Rui Dong Duan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Twenty-six plant species from the native flora used in Bolivian folk medicine were selected for studies of bioactivity. They belonged to the following families namely: Asteraceae (11), Brassicaceae (1), Cactaceae (1), Caesalpinaceae (2), Chenopodiaceae (1), Frankeniaceae (1), Geraniaceae (1), Laureaceae (1), Oxalidaceae (1), Piperaceae (1), Plantaginaceae (1), Rosaceae (1), Solanaceae (1) and Verbenaceae (2). Their effects on the proliferation of colon cancer cells (Caco-2) were studied using the WST-1 reagent. The results indicated that four out of 26 ethanolic extracts had a significant antiproliferative activity in this assay from (Schkuhria pinnata, Piper longestylosum, Parastrephia lepidophylla and Erodium cicutarium). The bioactivity of the extracts was correlated with the phytochemical characterization. Further studies of the mechanism of action of the bioactive extracts are needed.

Original languageEnglish
Pages (from-to)2204-2210
Number of pages7
JournalJournal of Medicinal Plants Research
Volume4
Issue number21
StatePublished - Nov 2010

Keywords

  • Bolivian plants
  • Cell proliferation
  • Colon cancer

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