Antiplasmodial activity of naphthoquinones related to lapachol and β-lapachone

Elisa Pérez-Sacau, Ana Estévez-Braun, Ángel G. Ravelo, David Gutiérrez Yapu, Alberto Giménez Turba

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and β-lapachone (2) was tested. Ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F 32 strain of Plasmodium falciparum, and some derivatives displayed attractive in vitro activities (IC 50 < 10 μM). Based on these results, some structure - activity relationships have been determined.

Original languageEnglish
Pages (from-to)264-274
Number of pages11
JournalChemistry and Biodiversity
Volume2
Issue number2
DOIs
StatePublished - 2005

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