Antiparasitic activity of two Brazilian plants: Eugenia mattosii and Marlierea eugeniopsoides

Giovana Vechi, Adrielli Tenfen, Efrain Salamanca Capusiri, Alberto Gimenez, Valdir Cechinel-Filho

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Parasitoses are very common throughout the world, generating serious consequences for public health. Leishmaniosis and giardiasis are examples of fairly recurrent, but neglected diseases. Several higher plants have demonstrated promising activity against the parasites. The aim of this study was to evaluate the biological activity of extracts, fractions and isolated compounds from the leaves and stems of two Brazilian plants: Eugenia mattosii and Marlierea eugeniopsoides (Myrtaceae) against Leishmania and Giardia. XTT and the fluorimetric method were used to for this evaluation, respectively. Cytotoxicity was evaluated against HeLa cells. The results demonstrated that chloroform fractions of E. matosii and pinostrobin presented the most pronounced antiparasitic activity, with the CLF-stems being the most effective against Leishmania amazonensis and Leishmania braziliensis. Pinostrobin also presented activity against G. lamblia. Therefore, E. mattosii stems and pinostrobin may be considered possible targets for the continuity of studies against other parasites.

Original languageEnglish
Pages (from-to)4876-4880
Number of pages5
JournalNatural Product Research
Volume35
Issue number22
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
The biological assays were partially financed by the UMSA-ASDI project Biomolecules of medicinal and industrial interest.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Eugenia mattosii
  • Giardia
  • Leishmania
  • cryptostrobin
  • parasites
  • pinostrobin

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