TY - JOUR
T1 - Antiparasitic activity of two Brazilian plants
T2 - Eugenia mattosii and Marlierea eugeniopsoides
AU - Vechi, Giovana
AU - Tenfen, Adrielli
AU - Capusiri, Efrain Salamanca
AU - Gimenez, Alberto
AU - Cechinel-Filho, Valdir
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Parasitoses are very common throughout the world, generating serious consequences for public health. Leishmaniosis and giardiasis are examples of fairly recurrent, but neglected diseases. Several higher plants have demonstrated promising activity against the parasites. The aim of this study was to evaluate the biological activity of extracts, fractions and isolated compounds from the leaves and stems of two Brazilian plants: Eugenia mattosii and Marlierea eugeniopsoides (Myrtaceae) against Leishmania and Giardia. XTT and the fluorimetric method were used to for this evaluation, respectively. Cytotoxicity was evaluated against HeLa cells. The results demonstrated that chloroform fractions of E. matosii and pinostrobin presented the most pronounced antiparasitic activity, with the CLF-stems being the most effective against Leishmania amazonensis and Leishmania braziliensis. Pinostrobin also presented activity against G. lamblia. Therefore, E. mattosii stems and pinostrobin may be considered possible targets for the continuity of studies against other parasites.
AB - Parasitoses are very common throughout the world, generating serious consequences for public health. Leishmaniosis and giardiasis are examples of fairly recurrent, but neglected diseases. Several higher plants have demonstrated promising activity against the parasites. The aim of this study was to evaluate the biological activity of extracts, fractions and isolated compounds from the leaves and stems of two Brazilian plants: Eugenia mattosii and Marlierea eugeniopsoides (Myrtaceae) against Leishmania and Giardia. XTT and the fluorimetric method were used to for this evaluation, respectively. Cytotoxicity was evaluated against HeLa cells. The results demonstrated that chloroform fractions of E. matosii and pinostrobin presented the most pronounced antiparasitic activity, with the CLF-stems being the most effective against Leishmania amazonensis and Leishmania braziliensis. Pinostrobin also presented activity against G. lamblia. Therefore, E. mattosii stems and pinostrobin may be considered possible targets for the continuity of studies against other parasites.
KW - Eugenia mattosii
KW - Giardia
KW - Leishmania
KW - cryptostrobin
KW - parasites
KW - pinostrobin
UR - http://www.scopus.com/inward/record.url?scp=85081721991&partnerID=8YFLogxK
U2 - 10.1080/14786419.2020.1739676
DO - 10.1080/14786419.2020.1739676
M3 - Artículo
AN - SCOPUS:85081721991
SN - 1478-6419
VL - 35
SP - 4876
EP - 4880
JO - Natural Product Research
JF - Natural Product Research
IS - 22
ER -