Antimalarial activity of some Colombian medicinal plants

G. Garavito, J. Rincón, L. Arteaga, Y. Hata, G. Bourdy, A. Gimenez, R. Pinzón, E. Deharo

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Antimalarial activity of 10 vegetal extracts (9 ethanolic extracts and 1 crude alkaloid extract), obtained from eight species traditionally used in Colombia to treat malaria symptoms, was evaluated in culture using Plasmodium falciparum chloroquine resistant (FcB2) strain and in vivo on rodent malaria Plasmodium berghei. The activity on ferriprotoporphyrin biomineralization inhibition test (FBIT) was also assessed. Against Plasmodium falciparum, eight extracts displayed good activity Abuta grandifolia (Mart.) Sandwith (Menispermaceae) leaves, Acacia farnesiana (L.) Willd. (Mimosaceae) leaves, Acnistus arborescens (L.) Schltdl. (Solanaceae) aerial part, Croton leptostachyus Kunth (Euphorbiaceae) aerial part, Piper cumanense Kunth (Piperaceae) fruits and leaves, Piper holtonii C. DC. (Piperaceae) aerial part and Xylopia aromatica (Lam.) Mart. (Annonaceae) bark with IC50 values ranging from <1 to 2.1 μg/ml, while in the in vivo model only Abuta grandifolia alkaloid crude extract exhibits activity, inhibiting 66% of the parasite growth at 250 mg/kg/day. In the FBIT model, five extracts were active (Abuta grandifolia, Croton leptostachyus, Piper cumanense fruit and leaves and Xylopia aromatica).

Original languageEnglish
Pages (from-to)460-462
Number of pages3
JournalJournal of Ethnopharmacology
Volume107
Issue number3
DOIs
StatePublished - 11 Oct 2006

Bibliographical note

Funding Information:
This work was supported by the Division de Investigaciones and the Departamento de Farmacia of the Universidad Nacional de Colombia and the CYTED X.5 Project.

Keywords

  • Antimalarials
  • Colombia
  • Malaria
  • Medicinal plants
  • Plasmodium

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