Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

V. Muñoz; Michel Sauvain; P. Mollinedo; J. Callapa; I. Rojas; A. Gimenez; A. Valentin; M. Mallié

doi:10.1055/s-2006-960808

Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

V. Muñoz, Michel Sauvain, P. Mollinedo, J. Callapa, I. Rojas, A. Gimenez, A. Valentin, M. Mallié

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43 Scopus citations

Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

Original language	English
Pages (from-to)	448-449
Number of pages	2
Journal	Planta Medica
Volume	65
Issue number	5
DOIs	https://doi.org/10.1055/s-2006-960808
State	Published - 1999

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abstract = "(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).",

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AU - Muñoz, V.

AU - Sauvain, Michel

AU - Mollinedo, P.

AU - Callapa, J.

AU - Rojas, I.

AU - Gimenez, A.

AU - Valentin, A.

AU - Mallié, M.

PY - 1999

Y1 - 1999

N2 - (-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

AB - (-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

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U2 - 10.1055/s-2006-960808

DO - 10.1055/s-2006-960808

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JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 5

ER -

Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Abstract

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