Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Victoria Muñoz Ortiz, Michel Sauvain, Patricia Andrea Mollinedo Portugal, J. Callapa, I. Rojas, Alberto José Gimenez Turba, A. Valentin, M. Mallié

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

Original languageEnglish
Pages (from-to)448-449
Number of pages2
JournalPlanta Medica
Volume65
Issue number5
DOIs
StatePublished - 1999

Fingerprint

Dive into the research topics of 'Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum'. Together they form a unique fingerprint.

Cite this