Antileishmanial metabolites from Trixis antimenorrhoea

Eliana M. Maldonado; Efrain Salamanca; Alberto Giménez; Gloria Saavedra; Olov Sterner

doi:10.1016/j.phytol.2014.10.017

Antileishmanial metabolites from Trixis antimenorrhoea

Eliana M. Maldonado, Efrain Salamanca, Alberto Giménez, Gloria Saavedra, Olov Sterner

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC₅₀ values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	Phytochemistry Letters
Volume	10
DOIs	https://doi.org/10.1016/j.phytol.2014.10.017
State	Published - Dec 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Keywords

Antileishmanial activity
Nortrixane
Structural elucidation
Trixanolide
Trixis antimenorrhoea

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10.1016/j.phytol.2014.10.017

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title = "Antileishmanial metabolites from Trixis antimenorrhoea",

abstract = "An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.",

keywords = "Antileishmanial activity, Nortrixane, Structural elucidation, Trixanolide, Trixis antimenorrhoea",

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year = "2014",

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volume = "10",

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journal = "Phytochemistry Letters",

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TY - JOUR

T1 - Antileishmanial metabolites from Trixis antimenorrhoea

AU - Maldonado, Eliana M.

AU - Salamanca, Efrain

AU - Giménez, Alberto

AU - Saavedra, Gloria

AU - Sterner, Olov

PY - 2014/12

Y1 - 2014/12

N2 - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.

AB - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.

KW - Antileishmanial activity

KW - Nortrixane

KW - Structural elucidation

KW - Trixanolide

KW - Trixis antimenorrhoea

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DO - 10.1016/j.phytol.2014.10.017

M3 - Artículo

AN - SCOPUS:84908454836

SN - 1874-3900

VL - 10

SP - 281

EP - 286

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Antileishmanial metabolites from Trixis antimenorrhoea

Abstract

Bibliographical note

Keywords

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