Abstract
An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.
Original language | English |
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Pages (from-to) | 281-286 |
Number of pages | 6 |
Journal | Phytochemistry Letters |
Volume | 10 |
DOIs | |
State | Published - Dec 2014 |
Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by the Swedish International Development Agency (SIDA) through a bilateral collaboration between Lund University (Sweden) and San Simón University (Bolivia). A special thank you is extended to Dr. Rikard Larsson for his guidance in the synthesis of the Mosher esters and helpful comments on the manuscript.
Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Keywords
- Antileishmanial activity
- Nortrixane
- Structural elucidation
- Trixanolide
- Trixis antimenorrhoea