Antileishmanial metabolites from Trixis antimenorrhoea

Eliana M. Maldonado, Efrain Salamanca, Alberto Giménez, Gloria Saavedra, Olov Sterner

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalPhytochemistry Letters
StatePublished - Dec 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.


  • Antileishmanial activity
  • Nortrixane
  • Structural elucidation
  • Trixanolide
  • Trixis antimenorrhoea


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