Antileishmanial metabolites from Lantana balansae

Eliana M. Maldonado, Efrain Salamanca, Alberto Giménez, Olov Sterner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalRevista Brasileira de Farmacognosia
Volume26
Issue number2
DOIs
StatePublished - 1 Jan 2016

Bibliographical note

Funding Information:
The financial support of the Swedish International Development Agency (SIDA) in a frame of collaboration agreement between Lund University (Sweden) and San Simón University (Bolivia) is gratefully acknowledged. We thank to Lic. Modesto Zárate for identifiying the plant.

Publisher Copyright:
© 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

Keywords

  • 12-oxo-phytodienoic acid
  • Flavonoids
  • L. braziliensis
  • Lantana balansae
  • Leishmania amazonensis

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