Antileishmanial metabolites from Lantana balansae

Eliana M. Maldonado, Efrain Salamanca, Alberto Giménez, Olov Sterner

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11 Scopus citations


Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalRevista Brasileira de Farmacognosia
Issue number2
StatePublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.


  • 12-oxo-phytodienoic acid
  • Flavonoids
  • L. braziliensis
  • Lantana balansae
  • Leishmania amazonensis


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