Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis

A. Fournet, A. Angelo Barrios, Victoria Muñoz Ortiz, R. Hocquemiller, F. Roblot, A. Cave

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39 Scopus citations

Abstract

The stem bark of Ampelocera edentula Kuhlm. (Ulmaceae) is used by the Chimanes Indians from Bolivia for the treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. A chloroform extract of the stem barks was found to be active against extracellular forms of Leishmania ssp. and Trypanosoma cruzi at 50 μg/ml. Bioassay-guided fractionation of this extract allowed us to isolate one active compound. Its structure was elucidated by spectral and chemical studies as 4-hydroxy-1-tetralone. BALB/c mice infected with L. amazonensis (PH8) or L. venezuelensis were treated one day after the parasitic infection with 4-hydroxy-1-tetralone (25 mg/kg/day) or with reference drug, Glucantime® (56 mg Sb(v)/kg disease severity. 4-Hydroxy-1-tetralone was slightly less effective than the reference drug against L. amazonensis or L. venezuelensis. Single treatment near the site of infection, 14 days after infection with L. amazonensis, with 4-hydroxy-1-tetralone (50 mg/kg) was more effective than Glucantime (112 mg/kg). This study is, to our knowledge, the first to show the activity of a tetralone for the experimental treatment of New World cutaneous leishmaniasis.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalPlanta Medica
Volume60
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Ampelocera edentula
  • cutaneous leishmaniasis
  • Leishmania ssp.
  • leishmanicidal activity
  • tetralone
  • trypanocidal activity
  • Trypanosoma cruzi
  • Ulmaceae

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