Antibiotics from basidiomycetes xl: Clavicoronic acid, a novel inhibitor of reverse transcriptases from clavicorona pyxidata (pers. ex fr.) doty

Gerhard Erkel, Timm Anke, Alberto José Gimenez Turba, Wolfgang Steglich

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68 μm) reverse transcriptases. In permeabilized cells and isolated nucleic DNA-and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalJournal of Antibiotics
Volume45
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Dive into the research topics of 'Antibiotics from basidiomycetes xl: Clavicoronic acid, a novel inhibitor of reverse transcriptases from clavicorona pyxidata (pers. ex fr.) doty'. Together they form a unique fingerprint.

Cite this