Antibacterial and leishmanicidal activity of Bolivian propolis

N. Nina; B. Lima; G. E. Feresin; Alberto José Gimenez Turba; E. Salamanca Capusiri; G. Schmeda-Hirschmann

doi:10.1111/lam.12543

Antibacterial and leishmanicidal activity of Bolivian propolis

N. Nina, B. Lima, G. E. Feresin, Alberto José Gimenez Turba, E. Salamanca Capusiri, G. Schmeda-Hirschmann

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the micro-broth dilution method against 11 bacterial pathogenic strains as well as against promastigotes of Leishmania amazonensis and L. braziliensis using the XTT-based colorimetric method. The methanolic extracts showed antibacterial effect ranging from inactive (MICs > 1000 μg ml^-1) to low (MICs 250-1000 μg ml^-1), moderate (62·5-125 μg ml^-1) and high antibacterial activity (MIC 31·2 μg ml^-1), according to the collection place and chemical composition. The most active samples towards Leishmania species were from Cochabamba and Tarija, with IC₅₀ values of 12·1 and 7·8, 8·0 and 10·9 μg ml^-1 against L. amazonensis and Leishmania brasiliensis respectively. The results show that the best antibacterial and antiprotozoal effect was observed for some phenolic-rich propolis.

Original language	English
Pages (from-to)	290-296
Number of pages	7
Journal	Letters in Applied Microbiology
Volume	62
Issue number	3
DOIs	https://doi.org/10.1111/lam.12543
State	Published - 1 Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 The Society for Applied Microbiology.

Keywords

Antibacterial activity
Bacteria
Bolivia
Disinfectant
Leishmanicidal activity
Phenolics
Propolis
Triterpenes

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title = "Antibacterial and leishmanicidal activity of Bolivian propolis",

abstract = "The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the micro-broth dilution method against 11 bacterial pathogenic strains as well as against promastigotes of Leishmania amazonensis and L. braziliensis using the XTT-based colorimetric method. The methanolic extracts showed antibacterial effect ranging from inactive (MICs > 1000 μg ml-1) to low (MICs 250-1000 μg ml-1), moderate (62·5-125 μg ml-1) and high antibacterial activity (MIC 31·2 μg ml-1), according to the collection place and chemical composition. The most active samples towards Leishmania species were from Cochabamba and Tarija, with IC50 values of 12·1 and 7·8, 8·0 and 10·9 μg ml-1 against L. amazonensis and Leishmania brasiliensis respectively. The results show that the best antibacterial and antiprotozoal effect was observed for some phenolic-rich propolis.",

keywords = "Antibacterial activity, Bacteria, Bolivia, Disinfectant, Leishmanicidal activity, Phenolics, Propolis, Triterpenes",

author = "N. Nina and B. Lima and Feresin, {G. E.} and {Gimenez Turba}, {Alberto Jos{\'e}} and {Salamanca Capusiri}, E. and G. Schmeda-Hirschmann",

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AU - Lima, B.

AU - Feresin, G. E.

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AU - Salamanca Capusiri, E.

AU - Schmeda-Hirschmann, G.

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N2 - The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the micro-broth dilution method against 11 bacterial pathogenic strains as well as against promastigotes of Leishmania amazonensis and L. braziliensis using the XTT-based colorimetric method. The methanolic extracts showed antibacterial effect ranging from inactive (MICs > 1000 μg ml-1) to low (MICs 250-1000 μg ml-1), moderate (62·5-125 μg ml-1) and high antibacterial activity (MIC 31·2 μg ml-1), according to the collection place and chemical composition. The most active samples towards Leishmania species were from Cochabamba and Tarija, with IC50 values of 12·1 and 7·8, 8·0 and 10·9 μg ml-1 against L. amazonensis and Leishmania brasiliensis respectively. The results show that the best antibacterial and antiprotozoal effect was observed for some phenolic-rich propolis.

AB - The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the micro-broth dilution method against 11 bacterial pathogenic strains as well as against promastigotes of Leishmania amazonensis and L. braziliensis using the XTT-based colorimetric method. The methanolic extracts showed antibacterial effect ranging from inactive (MICs > 1000 μg ml-1) to low (MICs 250-1000 μg ml-1), moderate (62·5-125 μg ml-1) and high antibacterial activity (MIC 31·2 μg ml-1), according to the collection place and chemical composition. The most active samples towards Leishmania species were from Cochabamba and Tarija, with IC50 values of 12·1 and 7·8, 8·0 and 10·9 μg ml-1 against L. amazonensis and Leishmania brasiliensis respectively. The results show that the best antibacterial and antiprotozoal effect was observed for some phenolic-rich propolis.

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KW - Leishmanicidal activity

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KW - Triterpenes

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Antibacterial and leishmanicidal activity of Bolivian propolis

Abstract

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Keywords

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