Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

Esther del Olmo; Marlon García Armas; Jose Luis López-Pérez; Grace Ruiz; Fernando Vargas; Alberto Giménez; Eric Deharo; Arturo San Feliciano

doi:10.1016/S0960-894X(01)00562-5

Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

Esther del Olmo, Marlon García Armas, Jose Luis López-Pérez, Grace Ruiz, Fernando Vargas, Alberto Giménez, Eric Deharo, Arturo San Feliciano

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

Original language	English
Pages (from-to)	2755-2757
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(01)00562-5
State	Published - 22 Oct 2001

Bibliographical note

Funding Information:
Financial support came from Spanish DGICYT (SAF 98/0103). M. G.-A. thanks the ICI-AECI (Spain) for a fellowship. Collaborative work was performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X. Biological evaluations were supported by the Institute de Recherche pour le Développement (IRD-France).

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title = "Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds",

abstract = "We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.",

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AU - Olmo, Esther del

AU - Armas, Marlon García

AU - López-Pérez, Jose Luis

AU - Ruiz, Grace

AU - Vargas, Fernando

AU - Giménez, Alberto

AU - Deharo, Eric

AU - Feliciano, Arturo San

N1 - Funding Information: Financial support came from Spanish DGICYT (SAF 98/0103). M. G.-A. thanks the ICI-AECI (Spain) for a fellowship. Collaborative work was performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X. Biological evaluations were supported by the Institute de Recherche pour le Développement (IRD-France).

PY - 2001/10/22

Y1 - 2001/10/22

N2 - We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

AB - We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

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DO - 10.1016/S0960-894X(01)00562-5

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 20

ER -

Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

Abstract

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