Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

Esther del Olmo, Marlon García Armas, Jose Luis López-Pérez, Grace Ruiz, Fernando Vargas, Alberto Giménez, Eric Deharo, Arturo San Feliciano

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We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

Original languageEnglish
Pages (from-to)2755-2757
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number20
StatePublished - 22 Oct 2001

Bibliographical note

Funding Information:
Financial support came from Spanish DGICYT (SAF 98/0103). M. G.-A. thanks the ICI-AECI (Spain) for a fellowship. Collaborative work was performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X. Biological evaluations were supported by the Institute de Recherche pour le Développement (IRD-France).


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