We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.
Bibliographical noteFunding Information:
Financial support came from Spanish DGICYT (SAF 98/0103). M. G.-A. thanks the ICI-AECI (Spain) for a fellowship. Collaborative work was performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X. Biological evaluations were supported by the Institute de Recherche pour le Développement (IRD-France).