Anti-leishmanial lindenane sesquiterpenes from hedyosmum angustifolium

Lucia Acebey; Valérie Jullian; Denis Sereno; Séverine Chevalley; Yannick Estevez; Claude Moulis; Stephan Beck; Alex Valentin; Alberto Gimenez; Michel Sauvain

doi:10.1055/s-0029-1186192

Anti-leishmanial lindenane sesquiterpenes from hedyosmum angustifolium

Lucia Acebey, Valérie Jullian, Denis Sereno, Séverine Chevalley, Yannick Estevez, Claude Moulis, Stephan Beck, Alex Valentin, Alberto Gimenez, Michel Sauvain

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of Hedyosmum angustifolium. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. angustifolium. The biological activities of 15 showed that onoseriolide (3) was the most active compound against axenic amastigotes from Leishmania amazonensis and L.infantum. Moreover, it was still active on the intramacrophagic amastigotes of L.infantum. The isolated compounds have also been tested on Plasmodium falciparum and against various mammalian cell lines.

Original language	English
Pages (from-to)	365-368
Number of pages	4
Journal	Planta Medica
Volume	76
Issue number	4
DOIs	https://doi.org/10.1055/s-0029-1186192
State	Published - 2010

Keywords

Antileishmanial
Chloranthaceae
Hedyosmum angustifolium
Intramacrophagic amastigotes
Lindenane sesquiterpene
Luciferase

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title = "Anti-leishmanial lindenane sesquiterpenes from hedyosmum angustifolium",

abstract = "The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of Hedyosmum angustifolium. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. angustifolium. The biological activities of 15 showed that onoseriolide (3) was the most active compound against axenic amastigotes from Leishmania amazonensis and L.infantum. Moreover, it was still active on the intramacrophagic amastigotes of L.infantum. The isolated compounds have also been tested on Plasmodium falciparum and against various mammalian cell lines.",

keywords = "Antileishmanial, Chloranthaceae, Hedyosmum angustifolium, Intramacrophagic amastigotes, Lindenane sesquiterpene, Luciferase",

author = "Lucia Acebey and Val{\'e}rie Jullian and Denis Sereno and S{\'e}verine Chevalley and Yannick Estevez and Claude Moulis and Stephan Beck and Alex Valentin and Alberto Gimenez and Michel Sauvain",

year = "2010",

doi = "10.1055/s-0029-1186192",

language = "Ingl{\'e}s",

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T1 - Anti-leishmanial lindenane sesquiterpenes from hedyosmum angustifolium

AU - Acebey, Lucia

AU - Jullian, Valérie

AU - Sereno, Denis

AU - Chevalley, Séverine

AU - Estevez, Yannick

AU - Moulis, Claude

AU - Beck, Stephan

AU - Valentin, Alex

AU - Gimenez, Alberto

AU - Sauvain, Michel

PY - 2010

Y1 - 2010

N2 - The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of Hedyosmum angustifolium. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. angustifolium. The biological activities of 15 showed that onoseriolide (3) was the most active compound against axenic amastigotes from Leishmania amazonensis and L.infantum. Moreover, it was still active on the intramacrophagic amastigotes of L.infantum. The isolated compounds have also been tested on Plasmodium falciparum and against various mammalian cell lines.

AB - The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of Hedyosmum angustifolium. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. angustifolium. The biological activities of 15 showed that onoseriolide (3) was the most active compound against axenic amastigotes from Leishmania amazonensis and L.infantum. Moreover, it was still active on the intramacrophagic amastigotes of L.infantum. The isolated compounds have also been tested on Plasmodium falciparum and against various mammalian cell lines.

KW - Antileishmanial

KW - Chloranthaceae

KW - Hedyosmum angustifolium

KW - Intramacrophagic amastigotes

KW - Lindenane sesquiterpene

KW - Luciferase

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U2 - 10.1055/s-0029-1186192

DO - 10.1055/s-0029-1186192

M3 - Artículo

C2 - 19830657

AN - SCOPUS:77749308324

SN - 0032-0943

VL - 76

SP - 365

EP - 368

JO - Planta Medica

JF - Planta Medica

IS - 4

ER -

Anti-leishmanial lindenane sesquiterpenes from hedyosmum angustifolium

Abstract

Keywords

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