Anti-infective assessment of Senecio smithioides (Asteraceae) and isolation of 9-oxoeuryopsin, a furanoeremophilane-type sesquiterpene with antiplasmodial activity

Patricia Mollinedo, José L. Vila, Hugo Arando, Michel Sauvain, Eric Deharo, José A. Bravo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The search for anti-infective activity in the antipyretic plant Senecio smithioides was conducted. Petroleum ether (PE), dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and hydroethanolic (96% EtOH) extracts, and compounds 9-oxoeuryopsin (1), epoxydecompostin (2) and senecionine (3) were obtained from the aerial parts. All extracts and 1 were tested against chloroquine-resistant strain of Plasmodium falciparum (ref. chloroquine), Trypanosoma cruzi (ref. nifurtimox), Leishmania braziliensis, Leishmania amazonensis and Leishmania donovani (ref. pentamidine), Staphylococcus aureus and Escherichia coli (ref. gentamicin) and, Neurospora crassa and Candida albicans (ref. ketoconazole). The PE extract exhibited the strongest in vitro activity against Plasmodium falciparum IC50 < 1.0 μg/mL. 1 was established as a potent antiplasmodial compound with an IC50 = 1.2 μg/mL, 5.2 μM. Other antiparasitic activities were recorded for all extracts and 1. Antibacterial and antifungal activity was negligible.

Original languageEnglish
Pages (from-to)2594-2597
Number of pages4
JournalNatural Product Research
Volume30
Issue number22
DOIs
StatePublished - 16 Nov 2016

Bibliographical note

Publisher Copyright:
© 2015 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Asteraceae
  • Plasmodium falciparum
  • Senecio smithioides
  • furanoeremophilane-type sesquiterpene
  • structural elucidation

Fingerprint

Dive into the research topics of 'Anti-infective assessment of Senecio smithioides (Asteraceae) and isolation of 9-oxoeuryopsin, a furanoeremophilane-type sesquiterpene with antiplasmodial activity'. Together they form a unique fingerprint.

Cite this