Activité antiparasit aire d'alcaloïdes bisbenzylisoquinoléiques. II: Activité in vitro sur des epimastigotes de trois souches typifiees de Trypanosoma cruzi

A. Fournet, A. M. Manjon, Victoria Muñoz Ortiz, A. Angelo, J. Bruneton, R. Hocquemiller, D. Cortes, A. Cavé

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Abstract

Chagas disease caused by the protozoan Trypanosoma cruzi is an endemic parasitic disease in Central and South America. The chemotherapic agents against Trypnosoma cruzi (imidazol compounds, lampit and benznidazol) are not very convenient products. Since it is known that protozoan Trypanosoma are close to Leishmania we studied the action of 14 bisbenzylisoquinoline alkaloids, in vitro, on three strains of T. cruzi (Tulahuen, C8C11, and 1979 CL1). As in the case of Leishmania, gyrocarpine, daphnandrine and obaberine showed an interesting activity and we judge them to be worthy of in vivo assays.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalJournal of Ethnopharmacology
Volume24
Issue number2-3
DOIs
StatePublished - Dec 1988
Externally publishedYes

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