Actividad antiplasmódica in vitro e inhibición de la formación de la β-hematina de plantas Colombianas de la familia annonaceae

Translated title of the contribution: In vitro antiplasmodial activity and inhibition of β-hematin formation of Colombian plants of the family annonaceae

Edison Osorio, Gabriel Arango, Edison García, Katalina Muñoz, Grace Ruiz, David Gutiérrez, Marco Antonio Paco, Alberto José Gimenez Turba

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The antiplasmodial activity of 36 plant extracts related to the Annonaceae family was tested on chloroquine sensitive strain F32 and chloroquine resistant strain W2 of Plasmodium falciparum. The capacity of inhibition of β-hematin formation (Ifβ-h) was also evaluated comparing both activities by means of a statistical correlation study. Four extracts presented a potent activity against F32 and three only showed activity against W2, being the hexane stem bark extract of Rollinia exsucca the most active with CI50 values of 3.0 and 4.8 μg/ml against F32 and W2, respectively. Only the ethyl acetate leaves extract of Desmopsis panamensis showed Ifβ-h activity and growth inhibition of both strain, while the ethyl acetate stem bark extract of Rollinia pittieri presents Ifβ-h activity and growth inhibition of F32. A low correlation was observed among both activities.

Translated title of the contributionIn vitro antiplasmodial activity and inhibition of β-hematin formation of Colombian plants of the family annonaceae
Original languageSpanish
Pages (from-to)527-532
Number of pages6
JournalActa Farmaceutica Bonaerense
Volume24
Issue number4
StatePublished - Oct 2005

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