A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part III. Evaluation of the antimalarial activity of plants used by Altenos Indians

Victoria Muñoz Ortiz, M. Sauvain, G. Bourdy, S. Arrázola, J. Callapa, Grace Ruiz, J. Choque, E. Deharo

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A total of 40 plant extracts traditionally used by the Altenos Indians, a native community living between the Andean block and the tropical valleys of Bolivia, were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine resistant (Indo) strain, and in vivo on rodent malaria Plasmodium vinckei petteri. Eleven extracts displayed good or moderate activity in vivo, and ten extracts good or very good antimalarial activity in vitro. Results of the screening are discussed here, in relation with the traditional use of plants. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalJournal of Ethnopharmacology
Volume71
Issue number1-2
DOIs
StatePublished - Jul 2000
Externally publishedYes

Bibliographical note

Funding Information:
The project was financed by FONAMA-EIA (Fondo Nacional para el Medio Ambiente, Cuenta Iniciativa para las Americas, Bolivia), IRD (l’institut de Recherche pour le Développement, France), UMSA (Universidad Mayor de San Andrés, La Paz, Bolivia), IBBA (Instituto Boliviano de Biologia de Altura, La Paz, Bolivia), the Ministry of French Foreign Affairs, and IFS (International Foundation for Sciences). The authors wish to thank B. Weniger for kindly help in the bibliographical search, and Rosy Chávez de Michel and the National Herbarium of Bolivia for helping in the management and determination of vouchers. We express our thanks to the members of the Alteños communities who were willing to share with us their knowledge about plants.

Keywords

  • Altenos
  • Antimalarial agents
  • Bolivia
  • Plasmodium
  • Quechua
  • Raqaypampenos
  • Traditional medicine

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