Seventy-seven plant extracts (corresponding to 62 different species) traditionally used by the Isoceño-Guaraní, a native community living in the Bolivian Chaco, were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine sensitive strain (F32), and on ferriprotoporphyrin (FP) IX biocrystallisation inhibition test (FBIT). Among these extracts, seven displayed strong in vitro antimalarial activity, and 25 were active in the FBIT test. Positive results on both tests were recorded for six extracts: Argemone subfusiformis aerial part, Aspidosperma quebracho-blanco bark, Castela coccinea leaves and bark, Solanum argentinum leaves and Vallesia glabra bark. Results are discussed in relation with Isoceño-Guaraní traditional medicine. Further studies to be undertaken in relation with these results are also highlighted.
Bibliographical noteFunding Information:
Collaborative work performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X and the Organisación de los Estados Americanos (OEA, Flora Regional). Ethnopharmacological survey and biological evaluations were supported by the Institut de Recherche pour le Développement (IRD-France). The authors wish to thank L.R. Chávez de Michel and the National Herbarium of Bolivia (HNB), for helping in the management and determination of voucher herbarium specimens. We express our thanks to members of the Guaranı́ community who were willing to share with us their knowledge about plants and to Rory Garcia who give us bark of Remijia peruviana for biological evaluation.
- Antimalarial drug
- Medicinal plants