A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti, M. Sauvain, C. Lavaud, G. Massiot, J. A. Bravo, Victoria Muñoz Ortiz

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

Original languageEnglish
Pages (from-to)1390-1393
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number11
DOIs
StatePublished - Nov 1998
Externally publishedYes

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